The Scriptures claim to be “God-Breathed” (θεόπνευστος , theopneustos, 2 Timothy 3:16, etc). That is either true of false. If true, it follows that God, being true, will not contradict what He alone has sanctioned and providentially preserved and decreed in His Holy and inerrant Word (John 17:17, Romans 3:4).
At the heart of all Biblical challenge is spiritual unbelief, not intellectual incompatibility, though the latter is often sited and held onto for dear life, ironic as that is, by those who professing themselves to be wise have become fools (Romans 1:20-21). In short, the θεόπνευστος (theopneustos, God-breathed) words of the living God have always been anathema to those who are unregenerate and know not the Shepherd in a saving way, for they do not hear, nor heed, his voice (John 10:5).
The doctrine of man’s total depravity explains this cause and effect. The reversal of the awful curse of sin in man (which curse, as a byproduct, includes placing our finite understanding above that of the infinite Creator) is only possible and wholly dependent upon the unconditional love of a dying Redeemer whose substitutionary atonement is alone effectual to the saving of souls inherently and utterly predisposed, and thus justly deserving, of physical and spiritual (hell) death.
When we challenge what God has said we must inevitable join Job and confess, “Who is he that hideth counsel without knowledge? therefore have I uttered that I understood not; things too wonderful for me, which I knew not... wherefore I abhor myself, and repent in dust and ashes “(Job 42:3,6).
We will either bow our knee in the day of grace or in a day of judgment (see Isaiah 45: 22-23 and Romans 14:11).